Changes in the intestinal microbiome of the preterm baby associated with stopping non-invasive pressure support: a prospective cohort study.

ABSTRACT:

Background

Intestinal dysbiosis is implicated in the pathogenesis of necrotising enterocolitis and late-onset sepsis in preterm babies. The provision of non-invasive positive pressure ventilation is a common clinical intervention in preterm babies, and may be hypothesised to adversely affect intestinal bacterial growth, through increased aerophagia and induction of a hyperoxic intestinal environment; however this relationship has not been previously well characterised.

Methodology

In this prospectively recruited cohort study, high-throughput 16S rRNA gene sequencing was combined with contemporaneous clinical data collection, to assess within-subject changes in microbiome development around the time of transitioning from non-invasive positive pressure respiratory support to u

SUBMITTER: Hutchinson R 

PROVIDER: S-EPMC11459353 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature