The essential kinase TgGSK regulates centrosome division and endodyogeny in <i>Toxoplasma gondii</i>.

ABSTRACT: Intracellular replication is crucial for the success of apicomplexan parasites, including Toxoplasma gondii. Therefore, essential players in parasite replication present potential targets for drug development. In this study, we have characterized TgGSK, a glycogen synthase kinase homolog that plays an important role in Toxoplasma endodyogeny. We have shown that TgGSK has a dynamic localization that is concurrent with the cell cycle. In non-dividing parasites, this kinase is highly concentrated in the nucleus. However, during division, TgGSK displays a cytosolic localization, with concentration foci at the centrosomes, a key organelle involved in parasite division, and the basal end. Conditional knockdown of TgGSK determined that it is essential for the completion of the lytic

SUBMITTER: Krueger A 

PROVIDER: S-EPMC11463552 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature