Pentadecanoic Acid-Releasing PDMS: Towards a New Material to Prevent <i>S. epidermidis</i> Biofilm Formation.

ABSTRACT: Microbial biofilm formation on medical devices paves the way for device-associated infections. Staphylococcus epidermidis is one of the most common strains involved in such infections as it is able to colonize numerous devices, such as intravenous catheters, prosthetic joints, and heart valves. We previously reported the antibiofilm activity against S. epidermidis of pentadecanoic acid (PDA) deposited by drop-casting on the silicon-based polymer poly(dimethyl)siloxane (PDMS). This material exerted an antibiofilm activity by releasing PDA; however, a toxic effect on bacterial cells was observed, which could potentially favor the emergence of resistant strains. To develop a PDA-functionalized material for medical use and overcome the problem of toxicity, we produced PDA-doped P

SUBMITTER: D'Angelo C 

PROVIDER: S-EPMC11476977 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature