Neurochemistry and functional connectivity in the brain of people with Charles Bonnet syndrome.

ABSTRACT:

Background

Charles Bonnet syndrome (CBS) is a condition in which people with vision loss experience complex visual hallucinations. These complex visual hallucinations may be caused by increased excitability in the visual cortex that are present in some people with vision loss but not others.

Objectives

We aimed to evaluate the association between γ-aminobutyric acid (GABA) in the visual cortex and CBS. We also tested the relationship among visually evoked responses, functional connectivity, and CBS.

Design

This is a prospective, case-controlled, cross-sectional observational study.

Methods

We applied 3-Tesla magnetic resonance spectroscopy, as well as task-based and resting state (RS) connectivity functional magnetic resonance imaging in six participants with C

SUBMITTER: Bridge H 

PROVIDER: S-EPMC11481065 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature