Venous-plexus-associated lymphoid hubs support meningeal humoral immunity.

ABSTRACT: There is increasing interest in how immune cells in the meninges-the membranes that surround the brain and spinal cord-contribute to homeostasis and disease in the central nervous system^1,2. The outer layer of the meninges, the dura mater, has recently been described to contain both innate and adaptive immune cells, and functions as a site for B cell development^3-6. Here we identify organized lymphoid structures that protect fenestrated vasculature in the dura mater. The most elaborate of these dural-associated lymphoid tissues (DALT) surrounded the rostral-rhinal confluence of the sinuses and included lymphatic vessels. We termed this structure, which interfaces with the skull bone marrow and a comparable venous plexus at the skull base, the rostral-rhinal venolympha

SUBMITTER: Fitzpatrick Z 

PROVIDER: S-EPMC11482273 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature