Parvimonas micra forms a distinct bacterial network with oral pathobionts in colorectal cancer patients.

ABSTRACT:

Background

Mounting evidence suggests a significant role of the gut microbiota in the development and progression of colorectal cancer (CRC). In particular, an over-representation of oral pathogens has been linked to CRC. The aim of this study was to further investigate the faecal microbial landscape of CRC patients, with a focus on the oral pathogens Parvimonas micra and Fusobacterium nucleatum.

Methods

In this study, 16S rRNA sequencing was conducted using faecal samples from CRC patients (n = 275) and controls without pathological findings (n = 95).

Results

We discovered a significant difference in microbial composition depending on tumour location and microsatellite instability (MSI) status, with P. micra, F. nucleatum, and Peptostreptococcus stomatis found to be

SUBMITTER: Lowenmark T 

PROVIDER: S-EPMC11487773 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature