PET imaging of CXCR4 expression using [¹⁸F]AlF-NOTA-QHY-04 for hematologic malignancy and solid tumors.

ABSTRACT: C-X-C motif chemokine receptor 4 (CXCR4) is an attractive target for the diagnosis and treatment of cancers. Here, we aimed to develop a new CXCR4-targeted PET tracer, and to investigate the translational potential for noninvasive imaging of CXCR4 expression in various cancer entities through preclinical and pilot clinical studies. Methods [¹⁸F]AlF-NOTA-QHY-04 was synthesized and evaluated by cellular uptake, blocking and biolayer interferometry studies in vitro. The pharmacokinetics, biodistribution, and imaging specificity were researched in tumor-bearing mice. [¹⁸F]AlF-NOTA-QHY-04 PET/CT imaging was performed on 55 patients with different types of cancers. Correlations between ex vivo CXCR4 expression and PET parameters, and CXCR4 expression ch

SUBMITTER: Cheng K 

PROVIDER: S-EPMC11488100 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature