Feasibility of multiorgan risk prediction with routinely collected diagnostics: a prospective cohort study in the UK Biobank.

ABSTRACT:

Objectives

Despite rising rates of multimorbidity, existing risk assessment tools are mostly limited to a single outcome of interest. This study tests the feasibility of producing multiple disease risk estimates with at least 70% discrimination (area under the receiver operating curve, AUROC) within the time and information constraints of the existing primary care health check framework.

Design

Observational prospective cohort study SETTING: UK Biobank.

Participants

228 240 adults from the UK population.

Interventions

None.

Main outcome measures

Myocardial infarction, atrial fibrillation, heart failure, stroke, all-cause dementia, chronic kidney disease, fatty liver disease, alcoholic liver disease, liver cirrhosis and liver failure.

Results

Using

SUBMITTER: McCracken C 

PROVIDER: S-EPMC11503151 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature