Relationship between donepezil and fracture risk in patients with dementia with Lewy bodies.

ABSTRACT:

Aim

Patients with dementia with Lewy bodies (DLB) are at a high risk for falls and fractures. Although cholinesterase inhibitors reportedly are effective in suppressing the progression of cognitive symptoms in DLB patients, their effects on fracture risk remain unclarified. This study aimed to evaluate the association between donepezil use and hip fracture risk in older patients with DLB.

Methods

Using the Japanese insurance claim database, we collected the data of patients aged ≥65 years with DLB from April 2012 to March 2019. After propensity score matching, we compared the fracture rate over 3 years between DLB patients receiving donepezil and those not receiving antidementia drugs.

Results

Altogether, 24 022 239 individuals aged ≥65 years were newly registered fro

SUBMITTER: Matsumoto S 

PROVIDER: S-EPMC11503602 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature