Landscape transcriptomic analysis of bovine follicular cells during key phases of ovarian follicular development.

ABSTRACT:

Background

There are many gaps in our understanding of the mechanisms involved in ovarian follicular development in cattle, particularly regarding follicular deviation, acquisition of ovulatory capacity, and preovulatory changes. Molecular evaluations of ovarian follicular cells during follicular development in cattle, especially serial transcriptomic analyses across key growth phases, have not been reported. This study aims to address this gap by analyzing gene expression using RNA-seq in granulosa and antral cells recovered from ovarian follicular fluid during critical phases of ovarian follicular development in Holstein cows.

Results

Integrated analysis of gene ontology (GO), gene set enrichment (GSEA), protein-protein interaction (PPI), and gene topology identified that

SUBMITTER: Mogollon Garcia HD 

PROVIDER: S-EPMC11514973 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature