Can we skip invasive biopsy of sentinel lymph nodes? A preliminary investigation to predict sentinel lymph node status using PET/CT-based radiomics.

ABSTRACT:

Background

Sentinel lymph node (SLN) biopsy (SLNB) is considered the gold standard for detecting SLN metastases in patients with invasive ductal breast cancer (IDC). However, SLNB is invasive and associated with several complications. Thus, this study aimed to evaluate the diagnostic performance of a non-invasive radiomics analysis utilizing 2-deoxy-2-[¹⁸F]fluoro-d-glucose positron emission tomography/computed tomography (¹⁸F-FDG-PET/CT) for assessing SLN metastasis in IDC patients.

Methods

This retrospective study included 132 patients with biopsy-confirmed IDC, who underwent ¹⁸F-FDG PET/CT scans prior to mastectomy or breast-conserving surgery with SLNB. Tumor resection or SLNB was conducted within one-week post-scan. Clinical data and meta

SUBMITTER: Yang L 

PROVIDER: S-EPMC11515836 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature