Diagnostic precision in thyroid-associated ophthalmopathy using multi-center radiomics with ^99mTc-DTPA SPECT/CT.

ABSTRACT: To explore the performance of ^99mTc-diethylene triaminepentaacetic acid (DTPA) SPECT/CT texture analysis in evaluating the activity of thyroid-associated ophthalmopathy (TAO) . This retrospective study examined 115 TAO patients from a single institution as an internal cohort and 58 TAO patients from another institution as an external validation set. Patients in the internal cohort were randomly divided into training (n = 81) and internal validation sets (n = 34). Radiomics signatures were constructed with the minimal redundancy maximal relevance and least absolute shrinkage and selection operator algorithms in training set. Multivariate logistic regression analysis was used to develop a clinical model and a combined clinical-radiomics model. Diagnostic performance of models was

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11519562 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature