Histone butyrylation in the mouse intestine is mediated by the microbiota and associated with regulation of gene expression.

ABSTRACT: Post-translational modifications (PTMs) on histones are a key source of regulation on chromatin through impacting cellular processes, including gene expression¹. These PTMs often arise from metabolites and are thus impacted by metabolism and environmental cues^2-7. One class of metabolically regulated PTMs are histone acylations, which include histone acetylation, butyrylation, crotonylation and propionylation^3,8. As these PTMs can be derived from short-chain fatty acids, which are generated by the commensal microbiota in the intestinal lumen^9-11, we aimed to define how microbes impact the host intestinal chromatin landscape, mainly in female mice. Here we show that in addition to acetylation, intestinal epithelial cells from the caecum and distal

SUBMITTER: Gates LA 

PROVIDER: S-EPMC11520355 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature