Tumour-stroma ratio (TSR) in breast cancer: comparison of scoring core biopsies versus resection specimens.

ABSTRACT:

Purpose

Tumour-stroma ratio (TSR) is an important prognostic and predictive factor in several tumour types. The aim of this study is to determine whether TSR evaluated in breast cancer core biopsies is representative of the whole tumour.

Method

Different TSR scoring methods, their reproducibility, and the association of TSR with clinicopathological characteristics were investigated in 178 breast carcinoma core biopsies and corresponding resection specimens. TSR was assessed by two trained scientists on the most representative H&E-stained digitised slides. Patients were treated primarily with surgery between 2010 and 2021 at Semmelweis University, Budapest.

Results

Ninety-one percent of the tumours were hormone receptor (HR)-positive (luminal-like). Interobserver agree

SUBMITTER: Karancsi Z 

PROVIDER: S-EPMC11522047 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature