D-mannose alleviates chronic periodontitis in rats by regulating the functions of neutrophils.

ABSTRACT:

Background

Periodontitis is a chronic inflammatory disease characterized by the destruction of the components of the periodontium. It significantly impacts oral health and has been linked to systemic conditions like cardiovascular disease and diabetes. The critical role of neutrophils in the occurrence and development of chronic periodontitis has been paid increasing attention. The study aimed to explore the protective effects of D-mannose on chronic periodontitis and determine whether its underlying mechanisms is related to neutrophils.

Methods

To explore the protective effects of D-mannose on chronic periodontitis, the eight-week-old Sprague Dawley rat model of lipopolysaccharide (LPS)-induced periodontitis was established, followed by D-mannose treatment by oral gavage. T

SUBMITTER: Li X 

PROVIDER: S-EPMC11529006 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature