Use of Therapeutic RNAs to Accelerate Wound Healing in Diabetic Rabbit Wounds.

ABSTRACT: Introduction: Diabetes mellitus (DM) affects over 422 million people globally. Patients with DM are subject to a myriad of complications, of which diabetic foot ulcers (DFUs) are the most common with ∼25% chance of developing these wounds throughout their lifetime. Innovation: Currently there are no therapeutic RNAs approved for use in DFUs. Use of dressings containing novel layer-by-layer (LbL)-formulated therapeutic RNAs that inhibit PHD2 and miR-210 can significantly improve diabetic wound healing. These dressings provide sustained release of therapeutic RNAs to the wounds locally without systemic side effects. Clinical Problem Addressed: Diabetic foot wounds are difficult to heal and often result in significant patient morbidity and mortality. Materials and Meth

SUBMITTER: Sumpio BJ 

PROVIDER: S-EPMC11535488 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature