Predicting acute lung injury in infants with congenital heart disease after cardiopulmonary bypass by gut microbiota.

ABSTRACT:

Background

Acute lung injury (ALI) is a serious and common complication that occurs in children with congenital heart disease after cardiopulmonary bypass (CPB) surgery, leading to higher mortality rates and poorer prognosis. Currently, there is no reliable predictive strategy for CPB-associated lung injury (CPB-ALI) in infants. Certain characteristics of the gut microbiota could potentially serve as biomarkers for predicting the development of CPB-ALI.

Methods

We conducted 16S rRNA sequencing to analyze the characteristics of the intestinal microbiota in healthy controls and infants with CHD admitted to the hospital. The CHD infants were divided into CPB-ALI and non-ALI (CPB-NALI) groups based on postoperative outcomes. Bacterial functional pathway prediction analysis was p

SUBMITTER: Jiang L 

PROVIDER: S-EPMC11540645 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature