Macrophage P2Y₆R activation aggravates psoriatic inflammation through IL-27-mediated Th1 responses.

ABSTRACT: Purinergic signaling plays a causal role in the modulation of immune inflammatory response in the course of psoriasis, but its regulatory mechanism remains unclear. As a member of purinoceptors, P2Y₆R mainly distributed in macrophages was significantly up-expressed in skin lesions from patients with psoriasis in the present study. Here, the severity of psoriasis was alleviated in imiquimod-treated mice with macrophages conditional knockout of P2Y₆R, while the cell-chat algorithm showed there was a correlation between macrophage P2Y₆R and Th1 cells mediated by IL-27. Mechanistically, P2Y₆R enhanced PLC _β /p-PKC/MAPK activation to induce IL-27 release dependently, which subsequently regulated the differentiation of Th1 cells, lead

SUBMITTER: Yin L 

PROVIDER: S-EPMC11544167 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature