Survival of Children With Critical Congenital Heart Defects in the National Birth Defects Prevention Study.

ABSTRACT:

Background

Critical congenital heart defects (CCHDs) are associated with considerable morbidity and mortality. This study estimated survival of children with nonsyndromic CCHDs and evaluated relationships between exposures of interest and survival by CCHD severity (univentricular or biventricular function).

Methods

This analysis included 4380 infants with CCHDs (cases) born during 1999-2011 and enrolled in the National Birth Defects Prevention Study, a multisite, population-based case-control study of major birth defects. Cases were linked to state death files. Nonparametric Kaplan-Meier survival functions were used to estimate 1- and 5-year survival probabilities overall and by severity group (univentricular/biventricular) stratified by demographic and clinical exposure var

SUBMITTER: Forestieri NE 

PROVIDER: S-EPMC11548799 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature