Frailty Trajectories Preceding Dementia in the US and UK.

ABSTRACT:

Importance

An accessible marker of both biological age and dementia risk is crucial to advancing dementia prevention and treatment strategies. Although frailty is a candidate for that role, the nature of the relationship between frailty and dementia is not well understood.

Objective

To clarify the temporal relationship between frailty and incident dementia by investigating frailty trajectories in the years preceding dementia onset.

Design, setting, and participants

Participant data came from 4 prospective cohort studies: the English Longitudinal Study of Ageing, the Health and Retirement Study, the Rush Memory and Aging Project, and the National Alzheimer Coordinating Center. Data were collected between 1997 and 2024 and were analyzed from July 2023 to August 2024. Th

SUBMITTER: Ward DD 

PROVIDER: S-EPMC11555573 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature