Red blood cell passage through deformable interendothelial slits in the spleen: Insights into splenic filtration and hemodynamics.

ABSTRACT: The spleen constantly clears altered red blood cells (RBCs) from the circulation, tuning the balance between RBC formation (erythropoiesis) and removal. The retention and elimination of RBCs occur predominantly in the open circulation of the spleen, where RBCs must cross submicron-wide inter-endothelial slits (IES). Several experimental and computational studies have illustrated the role of IES in filtrating the biomechanically and morphologically altered RBCs based on a rigid wall assumption. However, these studies also reported that when the size of IES is close to the lower end of clinically observed sizes (less than 0.5 μm), an unphysiologically large pressure difference across the IES is required to drive the passage of normal RBCs, sparking debates on the feasibility of the rigid wal

SUBMITTER: Li G 

PROVIDER: S-EPMC11560667 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature