Performance of Polygenic Risk Scores for Primary Open-Angle Glaucoma in Populations of African Descent.

ABSTRACT:

Importance

Primary open-angle glaucoma (POAG) polygenic risk scores (PRSs) continue to be evaluated in primarily European-ancestry populations despite higher prevalence and worse outcomes in African-ancestry populations.

Objective

To evaluate how established POAG PRSs perform in African-ancestry samples from the Genetics in Glaucoma Patients of African Descent (GIGA), Genetics of Glaucoma in Individuals of African Descent (GGLAD), and Million Veteran Program (MVP) datasets and compare these with European-ancestry samples.

Design, setting, and participants

This was a multicenter, cross-sectional study of POAG cases and controls from Tanzania, South Africa, Nigeria, Ghana, and the US. Included were individuals of African descent from South Africa and Tanzania from the G

SUBMITTER: Chang-Wolf JM 

PROVIDER: S-EPMC11565374 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature