Complex system modelling reveals oxalate homeostasis is driven by diverse oxalate-degrading bacteria.

ABSTRACT: Decades of research have made clear that host-associated microbiomes touch all facets of health. However, effective therapies that target the microbiome have been elusive given its inherent complexity. Here, we experimentally examined diet-microbe-host interactions through a complex systems framework, centered on dietary oxalate. Using multiple, independent molecular, animal, and in vitro experimental models, we found that microbiome composition influenced multiple oxalate-microbe-host interfaces. Importantly, administration of the oxalate-degrading specialist, Oxalobacter formigenes, was only effective against a poor oxalate-degrading microbiota background and gives critical new insights into why clinical intervention trials with this species exhibit variable outcomes. Data

SUBMITTER: Mukherjee SD 

PROVIDER: S-EPMC11565779 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature