Effect of oxyresveratrol under in vitro lipopolysaccharide-induced periodontitis environment.

ABSTRACT:

Background

Oxyresveratrol is the main constituent of mulberries and has many bioactive properties beneficial to human health. The purpose of this study was to assess the anti-inflammatory effects of oxyresveratrol on in vitro periodontitis model.

Methods

Human periodontal ligament cells were treated with oxyresveratrol (0, 10, and 20 µg/mL) for 72 h. Cell viability and flow cytometry assays were performed. To investigate anti-inflammatory effect of oxyresveratrol on periodontal inflammation, nitric oxide production under lipopolysaccharide stimulation was assessed. Next, expression of biomarkers associated periodontal inflammation was evaluated. Scratch wound assay was performed to evaluate cell migration/proliferation potential of oxyresveratrol under lipopolysaccharide sti

SUBMITTER: Ye JR 

PROVIDER: S-EPMC11566898 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature