NeuroBooster Array: A Genome-Wide Genotyping Platform to Study Neurological Disorders Across Diverse Populations.

ABSTRACT:

Background

Commercial genome-wide genotyping arrays have historically neglected coverage of genetic variation across populations.

Objective

We aimed to create a multi-ancestry genome-wide array that would include a wide range of neuro-specific genetic content to facilitate genetic research in neurological disorders across multiple ancestral groups, fostering diversity and inclusivity in research studies.

Methods

We developed the Illumina NeuroBooster Array (NBA), a custom high-throughput and cost-effective platform on a backbone of 1,914,934 variants from the Infinium Global Diversity Array and added custom content comprising 95,273 variants associated with more than 70 neurological conditions or traits, and we further tested its performance on more than 2000 patient

SUBMITTER: Bandres-Ciga S 

PROVIDER: S-EPMC11568947 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature