Hemoglobin vesicles improve neurological outcomes after cardiac arrest in rats.

ABSTRACT:

Aim

To investigate the effects of hemoglobin vesicles (HbVs) in preventing hypoxic brain injury after cardiac arrest in a rat model of asphyxia-related cardiac arrest.

Methods

Male Wistar rats were divided into three groups: HbVs (n = 18), control (n = 29), and sham (n = 7). Respiratory arrest was induced using muscle relaxants under ventilation. Cardiac arrest occurred 3-4 min later. After 8 min, HbVs or saline (5 ml/kg), adrenaline, and sodium bicarbonate were administered, followed by chest compressions and ventilation. Resuscitation was deemed successful with a mean arterial pressure > 60 mmHg sustained for at least 5 min. Behavioral and histopathological evaluations were performed 7 days later.

Results

Survival rates were 39 % and 24 % in the HbVs and control gro

SUBMITTER: Tsuruta K 

PROVIDER: S-EPMC11570973 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature