Prognostic value of tumor-infiltrating lymphocytes in distal extrahepatic bile duct carcinoma.

ABSTRACT:

Background

The assessment of tumor-infiltrating lymphocytes (TILs) has led to the development of various immunotherapies beyond their predictive potential in gastrointestinal malignancies. However, the clinicopathologic and prognostic values of TILs have yet to be well elucidated in distal extrahepatic bile duct carcinoma (DBDC).

Patients and methods

We evaluated stromal TILs (sTILs) and intraepithelial TILs (iTILs) in 405 surgically resected DBDCs to analyze their correlations with overall survival (OS) and recurrence-free survival (RFS) and with clinicopathologic parameters according to the eighth edition of the American Joint Committee on Cancer scheme.

Results

High levels of sTIL density (sTIL^High; >5%) and iTIL count (iTIL^High; >3) were foun

SUBMITTER: Jun SY 

PROVIDER: S-EPMC11575191 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature