Systemic Lipid Metabolism Dysregulation as a Possible Driving Force of Fracture Non-Unions?

ABSTRACT:

Introduction

Non-unions are fractures that do not heal properly, resulting in a false joint formation at the fracture site. This condition leads to major health issues and imposes a burden on national healthcare systems. The etiology of non-unions is still not fully understood; therefore, we aimed to identify potential systemic factors that may contribute to their formation.

Materials and methods

We conducted a cross-sectional concomitant proteomic and metabolomic pilot study of blood plasma in patients with non-unions (N = 11) and compared them with patients with bone fracture in the normal active healing phase (N = 12).

Results

We found five significantly upregulated proteins in the non-union group: immunoglobulin heavy variable 3-74, immunoglobulin lambda variable

SUBMITTER: Grgurevic L 

PROVIDER: S-EPMC11592249 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature