Electrical synapse molecular diversity revealed by proximity-based proteomic discovery.

ABSTRACT: Neuronal circuits are composed of synapses that are either chemical, where signals are transmitted via neurotransmitter release and reception, or electrical, where signals pass directly through interneuronal gap junction channels. While the molecular complexity that controls chemical synapse structure and function is well appreciated, the proteins of electrical synapses beyond the gap-junction-forming Connexins are not well defined. Yet, electrical synapses are expected to be molecularly complex beyond the gap junctions. Connexins are integral membrane proteins requiring vesicular transport and membrane insertion/retrieval to achieve function, homeostasis, and plasticity. Additionally, electron microscopy of neuronal gap junctions reveals neighboring electron dense regions termed the elect

SUBMITTER: Michel JC 

PROVIDER: S-EPMC11601576 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature