Quantitative analysis of islet prohormone convertase 1/3 expression in human pancreas donors with diabetes.

ABSTRACT:

Aims/hypothesis

Islet prohormone-processing enzymes convert peptide hormone precursors to mature hormones. Defective beta cell prohormone processing and the release of incompletely processed peptide hormones are observed prior to the onset of diabetes, yet molecular mechanisms underlying impaired prohormone processing during the development of diabetes remains largely unknown. Previous studies have shown that prohormone convertase 1/3 (PC1/3) protein and mRNA expression levels are reduced in whole islets from donors with type 1 diabetes, although whether PC1/3-mediated prohormone processing in alpha and beta cells is disrupted in type 1 diabetes remained to be explored. Herein, we aimed to analyse the expression of PC1/3 in islets from non-diabetic donors, autoantibody-positive don

SUBMITTER: Apaolaza PS 

PROVIDER: S-EPMC11604696 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature