Pan-Cancer Analysis of PTBP1 to Identify it as a Prognostic and Immunological Biomarker.

ABSTRACT:

Objectives

Human cancer is considered to be an important cause of death worldwide. Polypyrimidine tract binding protein 1 (PTBP1) is emerging as a powerful pro-oncogenic factor in bladder and liver cancer; however, no pan-cancer analysis is presently available. Our study aimed to explore PTBP1 expression profiles, prognostic immunological value, and biological functions across various cancers.

Methods

We conducted a comprehensive analysis using multi-omics bioinformatics from public databases, including TIMER, GEPIA2, ProteinAtlas, Kaplan-Meier Plotter, PrognoScan, cBioPortal, STRING, ENCORI, TargetScan, and DAVID.

Results

We found that PTBP1 was overexpressed across multiple cancer types. qRT-PCR results demonstrated that the PTBP1 mRNA was significantly up-regulated

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC11607764 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature