Protodefluorinated Selectfluor^® Aggregatively Activates Selectfluor^® for Efficient Radical C(sp³)-H Fluorination Reactions.

ABSTRACT: Efficient fluorination reactions are key in the late-stage functionalization of complex molecules in medicinal chemistry, in upgrading chemical feedstocks, and in materials science. Radical C(sp³)-H fluorinations using Selectfluor^® - one of the most popular fluorination agents - allow to directly engage unactivated precursors under mild photochemical or thermal catalytic conditions. However, H-TEDA(BF₄)₂ to date is overlooked and discarded as waste, despite comprising 95% of the molecular weight of Selectfluor^®. We demonstrate that the addition of H-TEDA(BF₄)₂ at the start of fluorination reactions markedly promotes their rates and accesses higher overall yields of fluorinated products (~3.3 × higher on average ac

SUBMITTER: Yakubov S 

PROVIDER: S-EPMC11632574 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature