PIAS family gene expression: implications for prognosis, immunomodulation, and chemotherapy response.

ABSTRACT:

Background

Cancer remains one of the leading causes of mortality worldwide, characterized by uncontrolled cell proliferation and metastasis. Protein Inhibitor of Activated STAT (PIAS) family genes, comprising PIAS1, PIAS2, PIAS3, and PIAS4, are emerging as significant players in cancer biology due to their roles in SUMOylation, transcriptional regulation, and modulation of signal transduction pathways. This study provides a comprehensive analysis of PIAS family genes from a pan-cancer viewpoint.

Methodology

Detailed in silico analyses using publicly available databases and in vitro analyses involving cell culture, gene knockdown, colony formation, and wound healing assays.

Results

Expression analysis revealed consistent up-regulation of PIAS1, PIAS2, PIAS3, and PIAS4

SUBMITTER: Shu H 

PROVIDER: S-EPMC11645565 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature