Vitamin B₁₂ produced by gut bacteria modulates cholinergic signalling.

ABSTRACT: A growing body of evidence indicates that gut microbiota influence brain function and behaviour. However, the molecular basis of how gut bacteria modulate host nervous system function is largely unknown. Here we show that vitamin B₁₂-producing bacteria that colonize the intestine can modulate excitatory cholinergic signalling and behaviour in the host Caenorhabditis elegans. Here we demonstrate that vitamin B₁₂ reduces cholinergic signalling in the nervous system through rewiring of the methionine (Met)/S-adenosylmethionine cycle in the intestine. We identify a conserved metabolic crosstalk between the methionine/S-adenosylmethionine cycle and the choline-oxidation pathway. In addition, we show that metabolic rewiring of these pathways by vitamin B₁₂ reduce

SUBMITTER: Kang WK 

PROVIDER: S-EPMC11650697 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature