Association between thyroid dysfunction and diabetic retinopathy: a two-sample bidirectional Mendelian randomization study.

ABSTRACT:

Objectives

To assess the association between thyroid dysfunction and diabetic retinopathy (DR), a two-sample bidirectional Mendelian randomization (MR) study utilizing the Genome-wide Association Study (GWAS) database was conducted to investigate the causal relationship between these two variables.

Methods

In this study, GWAS of 48,328,151 single nucleotide polymorphisms(SNP) in the European population from the IEU open GWAS database were utilized as genetic tools for investigating thyroid dysfunction. The total sample size for the study on hyperthyroidism was 460,499 (case group: 3557; control group: 456,942). The total sample size for hypothyroidism was 410,141 (case group: 30,155; control group: 37,986). In addition, the data on DR were extracted from the FinnGen Biobank,

SUBMITTER: Chen J 

PROVIDER: S-EPMC11657705 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature