Mutational disparities in colorectal cancers of White Americans, Alabama African Americans, And Oklahoma American Indians.

ABSTRACT: The high incidence and mortality rates of colorectal cancer (CRC) in Alabama African Americans (AAs) and Oklahoma American Indians (AIs) are recognized as cancer disparities, yet the underlying causes have been poorly demonstrated. By evaluating CRC whole-exome sequencing and mutational profiles, here we report sets of mutated genes whose frequencies differed significantly (p < 0.05) in a race-specific manner. Secondary screening with cancer database identified "survival-critical genes (SCGs)" (i.e., genes whose mutations/alterations are associated with significant differences in the patients' survival rates) among the differentially mutated genes. Notable SCGs with race-pronounced variants were different from DEGs and their involved pathways included nucleotide catabolism and cell cycle c

SUBMITTER: Yamada HY 

PROVIDER: S-EPMC11666716 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature