Genome-wide transcriptome analysis of Aβ deposition on PET in a Korean cohort.

ABSTRACT:

Introduction

Despite the recognized importance of including ethnic diversity in Alzheimer's disease (AD) research, substantial knowledge gaps remain, particularly in Asian populations.

Methods

RNA sequencing was performed on blood samples from the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease (KBASE) to perform differential gene expression (DGE), gene co-expression network, gene-set enrichment, and machine learning analyses for amyloid beta (Aβ) deposition on positron emission tomography.

Results

DGE analysis identified 265 dysregulated genes associated with Aβ deposition and replicated three AD-associated genes in an independent Korean cohort. Network analysis identified two modules related to pathways including a natural kill

SUBMITTER: Park T 

PROVIDER: S-EPMC11667488 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature