TEFM facilitates uterine corpus endometrial carcinoma progression by activating ROS-NFκB pathway.

ABSTRACT:

Background

Mitochondrial transcription elongation factor (TEFM) is a recently discovered factor involved in mitochondrial DNA replication and transcription. Previous studies have reported that abnormal TEFM expression can disrupt the assembly of mitochondrial respiratory chain and thus mitochondrial function. However, the role of TEFM on Uterine corpus endometrial carcinoma (UCEC) progression remains unclear. The present study aims to investigate the expression of TEFM in tumor tissue of UCEC and the effect of abnormal TEFM expression on malignant phenotype of UCEC cells.

Methods

The expressions of TEFM were measured in tumor tissues and cell lines of UCEC by immunohistochemistry, Western blotting, and real-time quantitative PCR assays. Besides, the effects of TEFM knockdown

SUBMITTER: Lei J 

PROVIDER: S-EPMC11673371 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature