Medullary Thyroid Carcinoma in the Background of Non-neoplastic Toxic Nodular Goiter.

ABSTRACT:

Background/objective

Medullary thyroid carcinoma (MTC) is an uncommon thyroid cancer (TC), rarely found in hyperfunctioning goiter.

Case report

We present a case of a woman treated for breast carcinoma (BCA) found to have a benign hyperfunctioning nodular goiter, its likely transformation to MTC, and its treatment. Family history revealed papillary thyroid cancer in her nephew.

Discussion

Most TCs in hyperfunctioning nodules are differentiated carcinomas. Familial MTC or MTC in association with multiple endocrine neoplasia 2 is the expected genetic association in this case.

Conclusion

The association of BCA and MTC may have been coincidental, given the high prevalence of BCA in females. It could have been the result of a common genetic precursor of both tumors

SUBMITTER: Rizwan A 

PROVIDER: S-EPMC11680752 | biostudies-literature | 2024 Nov-Dec

REPOSITORIES: biostudies-literature