MiR-193b-365 microcluster downstream of <i>Fezf2</i> coordinates neuron-subtype identity and dendritic morphology in cortical projection neurons.

ABSTRACT: Different neuron types develop characteristic axonal and dendritic arborizations that determine their inputs, outputs, and functions. Expression of fate-determinant transcription factors is essential for specification of their distinct identities. However, the mechanisms downstream of fate-determinant factors coordinating different aspects of neuron identity are not understood. Specifically, how distinct projection neurons develop appropriate dendritic arbors that determine their inputs is unknown. Here, we investigate this question in corticospinal and callosal projection neurons. We identified a mechanism linking the corticospinal/corticofugal identity gene Fezf2 with the regulation of dendritic development. We show that miR-193b∼365 microRNA cluster is regulated by Fezf2 a

SUBMITTER: Iyer A 

PROVIDER: S-EPMC11697703 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature