Accelerating Patterned Vascularization Using Granular Hydrogel Scaffolds and Surgical Micropuncture.

ABSTRACT: Bulk hydrogel scaffolds are common in reconstructive surgery. They allow for the staged repair of soft tissue loss by providing a base for revascularization. Unfortunately, they are limited by both slow and random vascularization, which may manifest as treatment failure or suboptimal repair. Rapidly inducing patterned vascularization within biomaterials has profound translational implications for current clinical treatment paradigms and the scaleup of regenerative engineering platforms. To address this long-standing challenge, a novel microsurgical approach and granular hydrogel scaffold (GHS) technology are co-developed to hasten and pattern microvascular network formation. In surgical micropuncture (MP), targeted recipient blood vessels are perforated using a microneedle to accelerate ce

SUBMITTER: Ataie Z 

PROVIDER: S-EPMC11699544 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature