From High Protection to Lethal Effect: Diverse Outcomes of Immunization Against Invasive Candidiasis with Different <i>Candida albicans</i> Extracellular Vesicles.

ABSTRACT: Extracellular vesicles (EVs) from Candida albicans can elicit immune responses, positioning them as promising acellular vaccine candidates. We characterized EVs from an avirulent C. albicans cell wall mutant (ecm33Δ) and evaluated their protective potential against invasive candidiasis. EVs from the yeast (YEVs) and hyphal (HEVs) forms of the SC5314 wild-type strain were also tested, yielding high survival rates with SC5314 YEV (91%) and ecm33 YEV immunization (64%). Surprisingly, HEV immunization showed a dual effect, resulting in 36% protection but also causing premature death in some mice. Proteomic analyses revealed distinct profiles among the top 100 proteins in the different EVs, which may explain these effects: a shared core of 50 immunogenic proteins suc

SUBMITTER: Martinez-Lopez R 

PROVIDER: S-EPMC11720215 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature