Multiple crosslinked, self-healing, and shape-adaptable hydrogel laden with pain-relieving chitosan@borneol nanoparticles for infected burn wound healing.

ABSTRACT: Rationale: Next-generation wound dressings with multiple biological functions hold promise for addressing the complications and pain associated with burn wounds. Methods: A hydrogel wound dressing loaded with a pain-relieving drug was developed for treating infected burn wounds. Polyvinyl alcohol chemically grafted with gallic acid (PVA-GA), sodium alginate chemically grafted with 3-aminobenzeneboronic acid (SA-PBA), Zn²⁺, and chitosan-coated borneol nanoparticles with anti-inflammatory and pain-relieving activities were combined to afford a nanoparticle-loaded hydrogel with a PVA-GA/Zn²⁺/SA-PBA network crosslinked via multiple physicochemical interactions. Results: The developed hydrogel demonstrated adhesiveness, self-healing, shape adaptability

SUBMITTER: Deng Z 

PROVIDER: S-EPMC11729554 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature