Discovery, Characterization, and Anti-XOD Activity of Calcium Metallophore from <i>Coix lacryma-jobi</i>.

ABSTRACT: In this work, coixalkyne A (1), a natural polynuclear calcium complex with a novel cross-shaped molecular architecture, was isolated from Coix lacryma-jobi L. along with the undescribed analogue coixalkyne B (2). Their structures were identified by means of NMR spectroscopy, ECD calculations, and single-crystal X-ray diffraction. It is noteworthy that the calcium ligands of 1 as well as compound 2 possess rare terminal alkynes and a nor-carbon sesquiterpene (C14) framework. The antihyperuricemic activity of C. lacryma-jobi and xanthine oxidase (XOD) inhibitory effects of 1-2 were elucidated by in vivo and in vitro assays, while the possible mechanism of action was suggested by molecular docking. Different from the

SUBMITTER: Xue Y 

PROVIDER: S-EPMC11731520 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature