The Pathogenic Role of Expanded CD8⁺CD28^null Angiogenic T Cells in ANCA-Associated Vasculitis.

ABSTRACT: Objectives: Angiogenic T cells (Tang) are crucial in promoting angiogenesis, with the loss of CD28 serving as a marker for highly differentiated and senescent T cells. This study aims to investigate the characteristics and potential roles of CD8⁺CD28^null Tang in patients with ANCA-associated vasculitis (AAV). Methods: A cohort of AAV patients and matched healthy controls (HCs) were analyzed. Flow cytometry was used to assess the profiles of circulating CD8⁺CD28^null Tang. In vitro functional assays were performed to evaluate the pathogenic properties of CD8⁺CD28^null Tang. Results: CD8⁺CD28^null Tang levels were significantly higher in the peripheral blood of AAV patients compared to H

SUBMITTER: Shen H 

PROVIDER: S-EPMC11760873 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature