Anthoteibinenes F-Q: New Sesquiterpenes from the Irish Deep-Sea Coral <i>Anthothela grandiflora</i>.

ABSTRACT: New technology has opened opportunities for research and exploration of deep-water ecosystems, highlighting deep-sea coral reefs as a rich source of novel bioactive natural products. During our ongoing investigation of the chemodiversity of the Irish deep sea and the soft coral Anthothela grandiflora, we report 12 unreported cadinene-like functionalized sesquiterpenes, anthoteibinenes F-Q. The metabolites were isolated using both bioassay- and ¹H NMR-guided approaches. One-/two-dimensional NMR spectroscopy and high-resolution mass spectrometry were used for structure elucidation, while a combination of NOESY NMR experiments, GIAO NMR calculations coupled with DP4+ probabilities measures, and ECD comparisons were incorporated to propose relative and absolute configurations

SUBMITTER: Olsen SSH 

PROVIDER: S-EPMC11767152 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature