Association of CSF soluble TREM1 levels with hippocampal atrophy in cognitively impaired older adults.

ABSTRACT:

Background

Recent studies have shown that cerebrospinal fluid (CSF) levels of soluble triggering receptor expressed on myeloid cells 1 (sTREM1) are elevated in individuals with Alzheimer's disease (AD), though the relationship between CSF sTREM1 and hippocampal atrophy remains to be elucidated. The primary aim of this study was to investigate the association between CSF sTREM1 levels and longitudinal changes in hippocampal volumes, and to determine if this relationship is moderated by cognitive status.

Methods

We included 576 participants, comprising 152 cognitively unimpaired (CU) and 424 cognitively impaired (CI) individuals. In the cross-sectional analyses, Pearson's correlation tests were conducted to examine the relationship between baseline CSF sTREM1 levels and hippoc

SUBMITTER: Shu H 

PROVIDER: S-EPMC11772463 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature