Serum Immunoglobulin G Levels and Nicastrin Variation in Hidradenitis Suppurativa.

ABSTRACT:

Importance

Variation in nicastrin (NCSTN) is associated with a monogenic subtype of hidradenitis suppurativa. Dysregulation of humoral immunity has been suggested as a potential mechanistic link between NCSTN variation and hidradenitis suppurativa. There is a paucity of biomarkers that can predict disease-associated variation.

Objective

To investigate whether serum immunoglobulin levels, as a surrogate marker of humoral immunity, can identify individuals with hidradenitis suppurativa who have a specific disease-associated NCSTN variant.

Design, setting, and participants

Maltese individuals with hidradenitis suppurativa genotyped for a disease-associated NCSTN in-frame deletion prevalent in the local patient cohort were invited to participate in this cross-sectional st

SUBMITTER: Mintoff D 

PROVIDER: S-EPMC11780503 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature