Plasma Alzheimer's disease biomarker variability: Amyloid-independent and amyloid-dependent factors.

ABSTRACT:

Introduction

We aimed to investigate which factors affect plasma biomarker levels via amyloid beta (Aβ)-independent or Aβ-dependent effects and improve the predictive performance of these biomarkers for Aβ positivity on positron emission tomography (PET).

Methods

A total of 2935 participants underwent blood sampling for measurements of plasma Aβ42/40 ratio, phosphorylated tau 217 (p-tau217; ALZpath), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) levels using single-molecule array and Aβ PET. Laboratory findings were collected using a routine blood test battery.

Results

Aβ-independent factors included hemoglobin and estimated glomerular filtration rate (eGFR) for p-tau217 and hemoglobin, eGFR, and triiodothyronine (T₃) for GFAP

SUBMITTER: Lee EH 

PROVIDER: S-EPMC11782842 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature