Cardiorespiratory fitness is associated with cognitive function in late adulthood: baseline findings from the IGNITE study.

ABSTRACT:

Objectives

To evaluate the association between cardiorespiratory fitness (CRF) and cognition in a large sample of older adults, and to examine clinical and demographic factors that might moderate these associations.

Methods

CRF was measured with a graded exercise test performed on a motorised treadmill. A confirmatory factor analysis was conducted using data from a comprehensive neuropsychological battery to obtain latent factors reflecting core cognitive domains. Linear regression models evaluated the association between CRF and each of the cognitive composites, and potential moderators including demographic factors (age, sex, education), apolipoprotein E ε4 (APOE4) carriage, beta-blocker use and components of maximal effort criteria during CRF testing.

Results

SUBMITTER: Oberlin LE 

PROVIDER: S-EPMC11790366 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature